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The researchers from Oregon and Spain point, in particular, to inadequate production of nitric oxide, an agent that relaxes and dilates blood vessels. — Inflammation promotes endothelial dysfunction and reduction of nitric oxide (NO), which is responsible for vascular relaxation including penile vessels. Chukwuemeka Osondu (Baptist Health South Florida), Bryan Vo (Florida International University), Ehimen Aneni (Mount Sinai Medical Center), and colleagues sought to establish erectile dysfunction as a simple and effective marker of underlying subclinical CV disease. A cardiologist reviewed electrocardiograms, lab findings and physician notes to confirm whether or not participants had in fact had experienced a medical event due to heart disease. Researcher May-Britt Tessem is heading up the team, which is affiliated with the MR Cancer Group at NTNU's Department of Circulation and Medical Imaging. This study was published online on March 7 in the journal Circulation. 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